No, this doesn't work with IPS. But what you could indeed do is storing a chacteristic pattern in variables, like [111111, 222222, 333333, 444444, 555555] in variables 0101-0105, and then write a program (or get somebody to write it) which scans the savegame file for this pattern in order to find these particular variables. This way you would find out where variables 0101-0105 are and so you also know where the other variables in the savegame are and you can change them.

(Well, a better way would be parsing the file, but I don't expect you to be able to do it. However I could do it for you if you tell me which variables you want to change to which values...)