Ok, ich hab die Lösung selbst gefunden - für alle, die das gleiche Problem haben wie ich...

"To anyone who has this problem and is using RealTek onboard audio :

First, make sure Hardware Audio is turned off in the game options.

Next, open your BIOEngine.ini in your "My Documents\Bioware\Mass Effect\Config\" folder. (I'd also recommend making a backup of the file, just in case)

Under the "[ISACTAudio.ISACTAudioDevice]" line, find "MaxChannels=" and "TotalAvailableChannels=". If the value for MaxChannels isn't 64, change it to 64 and change TotalAvailableChannels to 62."

Quelle: http://masseffect.bioware.com/forums...orum=127&sp=15