Neuer Ratschlag aus dem Biowareforum:

Zitat Zitat von Bioware-Foren
So, if your having problems, try this solution. Rename Paul.DLL to Paul.DLL.old and then try running the game. It will ask you to insert the DVD. Cancel out and close the game start. Then go back and rename Paul.DLL.old back to Paul.DLL and restart the game.

After that it looks like it was able to activate the license and has started correctly 10 times in a row for me. Now to go to work, Guess I'll have to play tonight, hehe.

Good luck, hope this helps.
Umbenennen von paul.dll in oldpaul.dll, zu starten versucht und anschließend wieder auf paul.dll umbennen.